Document Type

Article

Publication Date

2012

Subject: LCSH

RNA

Disciplines

Chemical Engineering | Chemistry | Mechanical Engineering

Abstract

We present computational models for the replication of double stranded RNA (dsRNA) or related macromolecules under thermal cycling conditions that would reflect prebiotic (i.e. non-enzymatic) environments. Two models of the replication of dsRNA are represented as multi-step chemical systems. The objective of this investigation was to better understand the kinetic features of such chemical systems. It is shown that thermal cycling in a chemical system is advantageous (relative to a fixed temperature) if there are two competing reactions, one favored at high temperature and one favored at low temperature. For the prebiotic replication of dsRNA, a high temperature favors formation of the two single stranded RNA (ssRNA) templates and a presumptive catalysis or catalytic surface is active at low temperature at which the ssRNA template is copied. Our models may facilitate understanding possible prebiotic conditions for the replication of dsRNA.

Comments

Open access.This work is licensed under a Creative Commons Attribution 3.0 License.

DOI

DOI: 10.5539/ijc.v4n5p9

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Publisher Citation

Schwartz, P., Lepore, D., & Barratt, C. (2012). Kinetic Models of the Prebiotic Replication of dsRNA under Thermal Cycling Conditions. International Journal of Chemistry, 4(5), 9-15. DOI: 10.5539/ijc.v4n5p9

Check your library

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.