Chemical Engineering | Chemistry | Mechanical Engineering
We present computational models for the replication of double stranded RNA (dsRNA) or related macromolecules under thermal cycling conditions that would reflect prebiotic (i.e. non-enzymatic) environments. Two models of the replication of dsRNA are represented as multi-step chemical systems. The objective of this investigation was to better understand the kinetic features of such chemical systems. It is shown that thermal cycling in a chemical system is advantageous (relative to a fixed temperature) if there are two competing reactions, one favored at high temperature and one favored at low temperature. For the prebiotic replication of dsRNA, a high temperature favors formation of the two single stranded RNA (ssRNA) templates and a presumptive catalysis or catalytic surface is active at low temperature at which the ssRNA template is copied. Our models may facilitate understanding possible prebiotic conditions for the replication of dsRNA.
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Schwartz, Pauline; Lepore, Dante M.; and Barratt, Carl, "Kinetic Models of the Prebiotic Replication of dsRNA under Thermal Cycling Conditions" (2012). Chemistry and Chemical Engineering Faculty Publications. 4.
Schwartz, P., Lepore, D., & Barratt, C. (2012). Kinetic Models of the Prebiotic Replication of dsRNA under Thermal Cycling Conditions. International Journal of Chemistry, 4(5), 9-15. DOI: 10.5539/ijc.v4n5p9