Document Type

Article

Publication Date

1-19-2016

MeSH Terms

Biotechnology, Dimethylpolysiloxanes, Nitric Oxide, polycarboxybetaine methacrylate

Subject: LCSH

Biotechnology, Polydimethylsiloxane, Nitric oxide

Disciplines

Biomedical Engineering and Bioengineering | Mechanical Engineering

Abstract

The functions of anti-fouling, zwitterionic polycarboxybetaine (pCB) and anti-platelet nitric oxide (NO) release replicate key anticoagulant properties of the endothelium. The two approaches, only tested separately thus far, were paired on gas permeable polydimethylsiloxane (PDMS) membranes and evaluated for anti-coagulation. Uncoated PDMS (control) and PDMS coated with pCB were screened for fibrinogen (Fg) fouling followed by platelet adsorption testing to evaluate the effects of coating and/or NO using bioreactors. Bare or coated PDMS membranes separated sheep plasma (108 platelets/ml) and gas flow chambers within the bioreactors. Either 100 or 0 ppm of NO/N2 flowed through the gas chamber for NO release at the plasma/biomaterial interface. Surface-adsorbed platelets were quantified using a lactate dehydrogenase assay after 8 hrs of plasma recirculation. Fg fouling and platelet adsorption on pCB-coated PDMS were 10.40 ± 3.0% of control (p

Comments

This is the peer reviewed version of the following article: Amoako, K. A., Sundaram, H. S., Suhaib, A., Jiang, S. and Cook, K. E. (2016), Multimodal, Biomaterial-Focused Anticoagulation via Superlow Fouling Zwitterionic Functional Groups Coupled with Anti-Platelet Nitric Oxide Release. Advanced Materials Interfaces, which has been published in final form at http://dx.doi.org/10.1002/admi.201500646. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

DOI

10.1002/admi.201500646

Publisher Citation

Amoako, K. A., Sundaram, H. S., Suhaib, A., Jiang, S. and Cook, K. E. (2016), Multimodal, Biomaterial-Focused Anticoagulation via Superlow Fouling Zwitterionic Functional Groups Coupled with Anti-Platelet Nitric Oxide Release. Advanced Materials Interfaces. Article first published online: 19 JAN 2016 doi: 10.1002/admi.201500646

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