Granulomatous Hepatitis Associated with Chronic Borrelia Burgdorferi Infection: a Case Report

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Publication Date


MeSH Terms

Lyme disease, Hepatitis

Subject: LCSH

Lyme disease, Hepatitis


Biology | Ecology and Evolutionary Biology


Although Lyme borreliosis has been linked to hepatitis in early stages of infection, the association of chronic Borrelia burgdorferi infection with hepatic disease remains largely unexplored. We present the case of a 53-year-old woman diagnosed with Lyme disease who developed acute hepatitis with elevated liver enzymes while on antibiotic treatment. Histological examination of liver biopsy tissue revealed spirochetes dispersed throughout the hepatic parenchyma, and the spirochetes were identified as Borrelia burgdorferi by molecular testing with specific DNA probes. Motile spirochetes were also isolated from the patient’s blood culture, and the isolate was identified as Borrelia burgdorferi sensu stricto by two independent laboratories using molecular techniques. These findings indicate that the patient had active, systemic Borrelia burgdorferi infection and consequent Lyme hepatitis, despite antibiotic therapy


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Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Publisher Citation

Middelveen MJ, McClain SA, Bandoski C, Israel JR, Burke J, AB, Timmaraju A, Sapi E, Wang Y, Franco A, Mayne PJ, and Stricker RB. (2014) Granulomatous hepatitis associated with chronic Borrelia burgdorferi infection: a case report. Research;1:875. http://dx.doi.org/10.13070/rs.en.1.875.