Document Type

Article

Publication Date

2018

MeSH Terms

Street Drugs--analysis, Counterfeit Drugs--analysis, Spectrum Analysis, Raman

Subject: LCSH

Raman spectroscopy, Drugs--Analysis, Product counterfeiting

Disciplines

Forensic Science and Technology

Abstract

Morphologically directed Raman spectroscopy (MDRS) is a novel tool for the forensic analysis of illicit and counterfeit drug samples. MDRS combines Raman microspectroscopy with automated particle imaging so that physical and chemical information about the components of a mixture sample can be obtained. Results of automated particle imaging are used to determine samples for Raman analysis. The use of MDRS for these types of samples can be employed for both forensic investigations and adjudications of cases. The method provides insight about the physical and chemical composition of the sample, as well as about manufacturing and sample history. Here, MDRS was used in four different illicit and counterfeit drug analyses: (1) examination of a multicomponent drug mixture where the results could be used for comparative source attribution, (2) the detection of low (or trace) concentration particles in a drug sample, (3) the analysis of synthetic cathinone samples (i.e., bath salts), and (4) a study of counterfeit pharmaceutical products.

Comments

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This is a post-peer review, pre-copyedit version of a chapter published in Methods in Molecular Biology: Analysis of Drugs of Abuse. The final authenticated version is available online at: http://dx.doi.org/10.1007/978-1-4939-8579-1_2

DOI

10.1007/978-1-4939-8579-1_2

Publisher Citation

Koutrakos, A. C., Leary, P. E., Kammrath, B. W. (2018). Illicit and Counterfeit Drug Analysis by Morphologically Directed Raman Spectroscopy. In Rabi Ann Musah, Ph.D. (Ed.), Methods in Molecular Biology: Analysis of Drugs of Abuse, pp. 13-27. Springer. ISBN: 978-1-4939-8579-1

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