Date of Submission
Master of Science in Computer Science
Electrical & Computer Engineering and Computer Science
Biosensing Techniques, Machine Learning, DNA Probes
Biosensors, Machine learning
In molecular biology, the term “DNA hybridization” generally refers to the process of forming a double stranded nucleic acid from joining two complementary strands of DNA. The degree of genetic similarity of the DNA resulting from hybridization can be detected ei ther by using the chemical characteristics of DNA samples or by utilizing reliable biosensors which transform the chemical characteristics into a source of electrical measurements. In past research about such sensors, known as DNA Hybridization Detection Systems, the thermal and electrical characteristics of carbon nanotubes are utilized to detect whether hybridization takes place or not. However, human interpretation of the measured data can lead to uncer tainty regarding, which compromises one crucial characteristic of biosensors—reliability. Research aimed at greater understanding of this sensor is still very much underway. This study is intended to make a signiﬁcant contribution to the growing ﬁeld of biotechnology by means of analyses of machine learning methods from a classiﬁcation perspective. The ultimate goal of this thesis is to see if any of the existing classiﬁcation algorithms, such as k-nearest neighbors and decision trees, are capable of predicting the state of hybridization based on simple electrical measurements. In this way, the machine learning algorithm uses real-life data to provide a systematic tool that can be utilized in various ﬁelds, such as bioinformatics, biomedicine, and forensic science.
Ang, Steven K., "A Machine Learning Technology for Rapid Detection of Carbon Nanotubes/DNA Hybridization in Biosensor Healthcare Applications" (2019). Master's Theses. 150.